Investigation of G007-LK treatment in mouse and human melanoma cell lines
Description
- Observed major zero expression levels through cell lines in each of treatment
Description
Results
Mouse gene expression analysis
- Only 346 significantly regulated genes out of 39075
- 0 handling making estimated treatment impact on expressions unsure.
Analysis of regulated Mouse genes across the 3 treatments
Approximately equal amounts of significantly regulated genes in each treatment
However, the overlap is very small
Discussion
The Human Analysis
PCA.1 The way the cell lines are segregated highlight the biological background outweighs the direct impact of the treatment in regards to gene expression variance
PCA.2 Outliers like SkMEL28 and A375, along with the distinctive positioning of WM852, suggested unique gene expression profiles potentially associated with the response to G007.LK.
This limitation in explaining variance by the principal components underscores the complex nature of gene expression changes in the human cell lines.
